BRD-K41337261_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K41337261_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AEBP1 AE binding protein 1
AKAP13 A kinase (PRKA) anchor protein 13
ALDOB aldolase B, fructose-bisphosphate
ANXA1 annexin A1
ASPN asporin
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLDN8 claudin 8
CNOT4 CCR4-NOT transcription complex, subunit 4
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CXORF57 chromosome X open reading frame 57
CYBRD1 cytochrome b reductase 1
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FRY furry homolog (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HIST1H2BG histone cluster 1, H2bg
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KLK5 kallikrein-related peptidase 5
KRT15 keratin 15, type I
KRT23 keratin 23, type I
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MSH2 mutS homolog 2
MXRA5 matrix-remodelling associated 5
MYO5C myosin VC
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
OLFM4 olfactomedin 4
PAWR PRKC, apoptosis, WT1, regulator
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PON3 paraoxonase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM30B transmembrane protein 30B
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDOC aldolase C, fructose-bisphosphate
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOE apolipoprotein E
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
CLDN10 claudin 10
CLGN calmegin
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
GPX1 glutathione peroxidase 1
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MFSD10 major facilitator superfamily domain containing 10
MGLL monoglyceride lipase
MLEC malectin
MRPS16 mitochondrial ribosomal protein S16
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIF peptidylprolyl isomerase F
PSD3 pleckstrin and Sec7 domain containing 3
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53BP2 tumor protein p53 binding protein 2
TSPO translocator protein (18kDa)
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
VKORC1 vitamin K epoxide reductase complex, subunit 1