BRD-K40955748_2-(4-(tert-butyl)benzamido)-4-chloro-5-fluorobenzoic acid KUC107739N_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K40955748_2-(4-(tert-butyl)benzamido)-4-chloro-5-fluorobenzoic acid KUC107739N_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSAT1 phosphoserine aminotransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
THBD thrombomodulin
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
CDC25A cell division cycle 25A
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
MEIS2 Meis homeobox 2
SFRP1 secreted frizzled-related protein 1
TMPRSS3 transmembrane protease, serine 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB18 zinc finger and BTB domain containing 18