BRD-K40919711_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K40919711_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCL6 B-cell CLL/lymphoma 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA3 EPH receptor A3
HEPH hephaestin
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NDRG1 N-myc downstream regulated 1
NKG7 natural killer cell granule protein 7
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKP phosphofructokinase, platelet
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDN peroxidasin
RBKS ribokinase
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
SAP30 Sin3A-associated protein, 30kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLAMF7 SLAM family member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX10 sorting nexin 10
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK26 serine/threonine protein kinase 26
TMEM47 transmembrane protein 47
TPSAB1 tryptase alpha/beta 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WSB1 WD repeat and SOCS box containing 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AURKB aurora kinase B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKAP4 cytoskeleton-associated protein 4
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
DPYD dihydropyrimidine dehydrogenase
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
LAMB1 laminin, beta 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAB21L2 mab-21-like 2 (C. elegans)
MUC16 mucin 16, cell surface associated
PVALB parvalbumin
RNF167 ring finger protein 167
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TPM1 tropomyosin 1 (alpha)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF586 zinc finger protein 586