BRD-K40853697_STAT3 Inhibitor VI, S31-201_CL34_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K40853697_STAT3 Inhibitor VI, S31-201_CL34_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP1 aquaporin 1 (Colton blood group)
BEX4 brain expressed, X-linked 4
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD36 CD36 molecule (thrombospondin receptor)
CFD complement factor D (adipsin)
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTSZ cathepsin Z
CYBB cytochrome b-245, beta polypeptide
DDR2 discoidin domain receptor tyrosine kinase 2
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
GIMAP5 GTPase, IMAP family member 5
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BG histone cluster 1, H2bg
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
KRT19 keratin 19, type I
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP19 matrix metallopeptidase 19
MYB v-myb avian myeloblastosis viral oncogene homolog
MYRF myelin regulatory factor
NEFL neurofilament, light polypeptide
NID2 nidogen 2 (osteonidogen)
NLRP2 NLR family, pyrin domain containing 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBX1 pre-B-cell leukemia homeobox 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP1 proteolipid protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SORBS2 sorbin and SH3 domain containing 2
SPARCL1 SPARC-like 1 (hevin)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMEM47 transmembrane protein 47
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
BAX BCL2-associated X protein
BMP2 bone morphogenetic protein 2
CALML5 calmodulin-like 5
CCNB2 cyclin B2
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLDN3 claudin 3
CLTB clathrin, light chain B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DERA deoxyribose-phosphate aldolase (putative)
DSG1 desmoglein 1
DUSP6 dual specificity phosphatase 6
ENOPH1 enolase-phosphatase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOPX HOP homeobox
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM3 interferon induced transmembrane protein 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KLK5 kallikrein-related peptidase 5
KRT1 keratin 1, type II
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP3 matrix metallopeptidase 3
MSLN mesothelin
OXA1L oxidase (cytochrome c) assembly 1-like
PCCB propionyl CoA carboxylase, beta polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLN phospholamban
PWP1 PWP1 homolog (S. cerevisiae)
RPIA ribose 5-phosphate isomerase A
RTN2 reticulon 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TXNL4A thioredoxin-like 4A
VDAC1 voltage-dependent anion channel 1