BRD-K40758391_cjd-pla-49-3_NCIH1694_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K40758391_cjd-pla-49-3_NCIH1694_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ASPH aspartate beta-hydroxylase
ATM ATM serine/threonine kinase
BACE2 beta-site APP-cleaving enzyme 2
BIRC3 baculoviral IAP repeat containing 3
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN4 claudin 4
CLIC3 chloride intracellular channel 3
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPD carboxypeptidase D
CPT1A carnitine palmitoyltransferase 1A (liver)
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EGFL6 EGF-like-domain, multiple 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
ERAP2 endoplasmic reticulum aminopeptidase 2
FGG fibrinogen gamma chain
FKBP10 FK506 binding protein 10, 65 kDa
FMO1 flavin containing monooxygenase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HLA-C major histocompatibility complex, class I, C
IGL immunoglobulin lambda locus
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
ITGB7 integrin, beta 7
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LOX lysyl oxidase
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALL mal, T-cell differentiation protein-like
MET MET proto-oncogene, receptor tyrosine kinase
MYLK myosin light chain kinase
NID2 nidogen 2 (osteonidogen)
NOTCH2 notch 2
NPR3 natriuretic peptide receptor 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCP4 Purkinje cell protein 4
PCYOX1 prenylcysteine oxidase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PHACTR2 phosphatase and actin regulator 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PRSS21 protease, serine, 21 (testisin)
PTGES prostaglandin E synthase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
S100P S100 calcium binding protein P
SAMD9 sterile alpha motif domain containing 9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCEL sciellin
SDPR serum deprivation response
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SIRT3 sirtuin 3
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SRGN serglycin
STAT4 signal transducer and activator of transcription 4
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
VCAN versican
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
C14ORF2 chromosome 14 open reading frame 2
C2CD5 C2 calcium-dependent domain containing 5
CANT1 calcium activated nucleotidase 1
CDC20 cell division cycle 20
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLTB clathrin, light chain B
COPS7A COP9 signalosome subunit 7A
CRIP2 cysteine-rich protein 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSRP2 cysteine and glycine-rich protein 2
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5 eukaryotic translation initiation factor 5
ENOPH1 enolase-phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP7 fatty acid binding protein 7, brain
FBXO21 F-box protein 21
FRZB frizzled-related protein
FSD1 fibronectin type III and SPRY domain containing 1
FXYD6 FXYD domain containing ion transport regulator 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100129361
LONP1 lon peptidase 1, mitochondrial
MEIS2 Meis homeobox 2
MLF2 myeloid leukemia factor 2
MRPS35 mitochondrial ribosomal protein S35
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTA1 metastasis associated 1
MTF2 metal response element binding transcription factor 2
NSG1 neuron specific gene family member 1
PCIF1 PDX1 C-terminal inhibiting factor 1
PGAM1 phosphoglycerate mutase 1 (brain)
PID1 phosphotyrosine interaction domain containing 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTK2 protein tyrosine kinase 2
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
PXDN peroxidasin
REG3A regenerating islet-derived 3 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
RGS4 regulator of G-protein signaling 4
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNPS1 RNA binding protein S1, serine-rich domain
RPIA ribose 5-phosphate isomerase A
RTN1 reticulon 1
RTN2 reticulon 2
SAMD4A sterile alpha motif domain containing 4A
SCAND1 SCAN domain containing 1
SCG2 secretogranin II
SCG3 secretogranin III
SESN1 sestrin 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TDG thymine-DNA glycosylase
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOX thymocyte selection-associated high mobility group box
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
VDAC1 voltage-dependent anion channel 1
WBP11 WW domain binding protein 11
WDTC1 WD and tetratricopeptide repeats 1
ZNF232 zinc finger protein 232
ZNF423 zinc finger protein 423