BRD-K40441731_N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-(trifluoromethyl)benzamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

31 genes differentially expressed following the BRD-K40441731_N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-(trifluoromethyl)benzamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
HOXC6 homeobox C6
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CLIC5 chloride intracellular channel 5
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LRRC41 leucine rich repeat containing 41
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
NSDHL NAD(P) dependent steroid dehydrogenase-like
PEG10 paternally expressed 10
RGCC regulator of cell cycle
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SQLE squalene epoxidase
TIMP3 TIMP metallopeptidase inhibitor 3