BRD-K40175214_torin-1_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K40175214_torin-1_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
BCAS3 breast carcinoma amplified sequence 3
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL4A1 collagen, type IV, alpha 1
CTSB cathepsin B
CTSE cathepsin E
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDR1 discoidin domain receptor tyrosine kinase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FN1 fibronectin 1
FZD5 frizzled class receptor 5
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAM3 junctional adhesion molecule 3
KCTD12 potassium channel tetramerization domain containing 12
KIAA1033 KIAA1033
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NARFL nuclear prelamin A recognition factor-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SCAMP1 secretory carrier membrane protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM100 transmembrane protein 100
TOM1L1 target of myb1 (chicken)-like 1
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VCAN versican
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
C11ORF24 chromosome 11 open reading frame 24
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CENPU centromere protein U
COL1A1 collagen, type I, alpha 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EI24 etoposide induced 2.4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
ICMT isoprenylcysteine carboxyl methyltransferase
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
LMNB1 lamin B1
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MFSD10 major facilitator superfamily domain containing 10
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRA methionine sulfoxide reductase A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PSPH phosphoserine phosphatase
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SPATS2L spermatogenesis associated, serine-rich 2-like
SRM spermidine synthase
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZW10 zw10 kinetochore protein