BRD-K40175214_torin-1_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K40175214_torin-1_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BCAS3 breast carcinoma amplified sequence 3
BHLHE41 basic helix-loop-helix family, member e41
C1ORF106 chromosome 1 open reading frame 106
CAST calpastatin
CCNG2 cyclin G2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHN1 chimerin 1
COCH cochlin
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO4 forkhead box O4
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIF5C kinesin family member 5C
KLHL24 kelch-like family member 24
MARCKSL1 MARCKS-like 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NCK2 NCK adaptor protein 2
NSG1 neuron specific gene family member 1
OPHN1 oligophrenin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAMD4A sterile alpha motif domain containing 4A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SORBS3 sorbin and SH3 domain containing 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BAG3 BCL2-associated athanogene 3
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CDC6 cell division cycle 6
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
FKBP14 FK506 binding protein 14, 22 kDa
KIAA0101 KIAA0101
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MME membrane metallo-endopeptidase
NME1 NME/NM23 nucleoside diphosphate kinase 1
PFN2 profilin 2
PGC progastricsin (pepsinogen C)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TK1 thymidine kinase 1, soluble
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3