BRD-K40175214_torin-1_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

249 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
BPHL biphenyl hydrolase-like (serine hydrolase)
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CHN1 chimerin 1
CHN2 chimerin 2
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL10A1 collagen, type X, alpha 1
COL6A1 collagen, type VI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CREB1 cAMP responsive element binding protein 1
DEFB1 defensin, beta 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DSP desmoplakin
EFNB2 ephrin-B2
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4A1 eukaryotic translation initiation factor 4A1
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FN1 fibronectin 1
FNBP1 formin binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
HIST3H2A histone cluster 3, H2a
HMGA2 high mobility group AT-hook 2
HOXD1 homeobox D1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KLK8 kallikrein-related peptidase 8
LAMC2 laminin, gamma 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MMP11 matrix metallopeptidase 11
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE9A phosphodiesterase 9A
PILRB paired immunoglobin-like type 2 receptor beta
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLXNA1 plexin A1
PNRC1 proline-rich nuclear receptor coactivator 1
PTPRO protein tyrosine phosphatase, receptor type, O
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXDC1 PX domain containing 1
RAB40B RAB40B, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RGS10 regulator of G-protein signaling 10
RIPK4 receptor-interacting serine-threonine kinase 4
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC35E2B solute carrier family 35, member E2B
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STAB1 stabilin 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPRSS3 transmembrane protease, serine 3
TPP1 tripeptidyl peptidase I
TPR translocated promoter region, nuclear basket protein
TRA2A transformer 2 alpha homolog (Drosophila)
TRAK2 trafficking protein, kinesin binding 2
TRAPPC6A trafficking protein particle complex 6A
TSPAN5 tetraspanin 5
TTC17 tetratricopeptide repeat domain 17
TTC3 tetratricopeptide repeat domain 3
UBE2B ubiquitin-conjugating enzyme E2B
VAT1 vesicle amine transport 1
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF264 zinc finger protein 264
ZNF266 zinc finger protein 266
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZNF331 zinc finger protein 331
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CCL19 chemokine (C-C motif) ligand 19
CCND3 cyclin D3
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CFH complement factor H
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
CTSC cathepsin C
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUOX2 dual oxidase 2
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
G6PD glucose-6-phosphate dehydrogenase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HAT1 histone acetyltransferase 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MARS methionyl-tRNA synthetase
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NSF N-ethylmaleimide-sensitive factor
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PEX11A peroxisomal biogenesis factor 11 alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100A11 S100 calcium binding protein A11
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELT selenoprotein T
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
TARS threonyl-tRNA synthetase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECR trans-2,3-enoyl-CoA reductase
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPO thymopoietin
TRIM16 tripartite motif containing 16
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein