BRD-K40175214_torin-1_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

217 genes differentially expressed following the BRD-K40175214_torin-1_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
ANKRD28 ankyrin repeat domain 28
APOD apolipoprotein D
ATF4 activating transcription factor 4
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATXN1 ataxin 1
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTTN cortactin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
EIF3D eukaryotic translation initiation factor 3, subunit D
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FA2H fatty acid 2-hydroxylase
FAM50A family with sequence similarity 50, member A
FHL2 four and a half LIM domains 2
FNTA farnesyltransferase, CAAX box, alpha
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
IDS iduronate 2-sulfatase
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KLHL24 kelch-like family member 24
LAPTM5 lysosomal protein transmembrane 5
LPIN1 lipin 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1B microtubule-associated protein 1B
MGLL monoglyceride lipase
MIA melanoma inhibitory activity
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PKN1 protein kinase N1
PLCB4 phospholipase C, beta 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLLP plasmolipin
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PXDC1 PX domain containing 1
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RIOK3 RIO kinase 3
RRAGD Ras-related GTP binding D
SATB1 SATB homeobox 1
SMAD3 SMAD family member 3
SOX10 SRY (sex determining region Y)-box 10
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
UBXN7 UBX domain protein 7
UFM1 ubiquitin-fold modifier 1
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ATAD2 ATPase family, AAA domain containing 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
C1S complement component 1, s subcomponent
C7 complement component 7
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD93 CD93 molecule
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CFB complement factor B
CFI complement factor I
CHEK2 checkpoint kinase 2
CLIC3 chloride intracellular channel 3
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FSTL1 follistatin-like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
OASL 2'-5'-oligoadenylate synthetase-like
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRDX2 peroxiredoxin 2
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
RAD51C RAD51 paralog C
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RSAD2 radical S-adenosyl methionine domain containing 2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
TAGLN transgelin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TSPAN13 tetraspanin 13
TTN titin
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein