BRD-K40175214_torin-1_BT20_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K40175214_torin-1_BT20_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
CASC3 cancer susceptibility candidate 3
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CYLD cylindromatosis (turban tumor syndrome)
CYTH1 cytohesin 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBN2 fibrillin 2
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR137B G protein-coupled receptor 137B
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
JMJD1C jumonji domain containing 1C
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MLPH melanophilin
MPO myeloperoxidase
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
RALGDS ral guanine nucleotide dissociation stimulator
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RTN2 reticulon 2
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBX3 T-box 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM63A transmembrane protein 63A
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
C3 complement component 3
CAPN2 calpain 2, (m/II) large subunit
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTA1 glutathione S-transferase alpha 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
KLF4 Kruppel-like factor 4 (gut)
LRRC59 leucine rich repeat containing 59
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPHOSPH6 M-phase phosphoprotein 6
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCH2 mitochondrial carrier 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP16 NOP16 nucleolar protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A6 S100 calcium binding protein A6
SDF2L1 stromal cell-derived factor 2-like 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein