BRD-K40175214_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K40175214_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ANKRD28 ankyrin repeat domain 28
AQP3 aquaporin 3 (Gill blood group)
ATF4 activating transcription factor 4
BZW2 basic leucine zipper and W2 domains 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRNP2 cysteine-serine-rich nuclear protein 2
DDIT3 DNA-damage-inducible transcript 3
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
ERBB3 erb-b2 receptor tyrosine kinase 3
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MXI1 MAX interactor 1, dimerization protein
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
OXTR oxytocin receptor
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
PRAF2 PRA1 domain family, member 2
RAB5A RAB5A, member RAS oncogene family
RIOK3 RIO kinase 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SOX10 SRY (sex determining region Y)-box 10
TANK TRAF family member-associated NFKB activator
TEX10 testis expressed 10
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
B3GNT1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCND3 cyclin D3
CD14 CD14 molecule
CD163 CD163 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DERA deoxyribose-phosphate aldolase (putative)
DPT dermatopontin
FAM162A family with sequence similarity 162, member A
FCGBP Fc fragment of IgG binding protein
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RANBP1 RAN binding protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SST somatostatin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3