BRD-K39829853_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K39829853_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCND2 cyclin D2
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDA cytidine deaminase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN3 chloride channel, voltage-sensitive 3
COG5 component of oligomeric golgi complex 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ENO2 enolase 2 (gamma, neuronal)
EPRS glutamyl-prolyl-tRNA synthetase
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
KDM7A lysine (K)-specific demethylase 7A
KIAA1598
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT81 keratin 81, type II
KYNU kynureninase
LCN2 lipocalin 2
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MINA MYC induced nuclear antigen
MTA1 metastasis associated 1
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PECAM1 platelet/endothelial cell adhesion molecule 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
UFM1 ubiquitin-fold modifier 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CCNE2 cyclin E2
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFR3A EFR3 homolog A (S. cerevisiae)
EXPH5 exophilin 5
FEN1 flap structure-specific endonuclease 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN2 high mobility group nucleosomal binding domain 2
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
ITGB1BP1 integrin beta 1 binding protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPH non-SMC condensin I complex, subunit H
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
ORC1 origin recognition complex, subunit 1
PAM peptidylglycine alpha-amidating monooxygenase
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
TK1 thymidine kinase 1, soluble
TRAPPC3 trafficking protein particle complex 3
TUBB6 tubulin, beta 6 class V
XIST X inactive specific transcript (non-protein coding)