BRD-K39829853_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K39829853_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALML5 calmodulin-like 5
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
COG5 component of oligomeric golgi complex 5
COL9A3 collagen, type IX, alpha 3
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
FGF13 fibroblast growth factor 13
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBE1 glucan (1,4-alpha-), branching enzyme 1
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IQCG IQ motif containing G
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KRT6B keratin 6B, type II
KYNU kynureninase
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAB38 RAB38, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SPAG4 sperm associated antigen 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANXA1 annexin A1
BID BH3 interacting domain death agonist
CD93 CD93 molecule
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
FHL1 four and a half LIM domains 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IL1R1 interleukin 1 receptor, type I
KCTD12 potassium channel tetramerization domain containing 12
KRT13 keratin 13, type I
LEPR leptin receptor
LPAR6 lysophosphatidic acid receptor 6
METRN meteorin, glial cell differentiation regulator
MSMB microseminoprotein, beta-
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
OBSL1 obscurin-like 1
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SPON1 spondin 1, extracellular matrix protein
TNS1 tensin 1
TSPYL5 TSPY-like 5