BRD-K39829853_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K39829853_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAA1 acetyl-CoA acyltransferase 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A2 collagen, type VI, alpha 2
CRAT carnitine O-acetyltransferase
CRISP3 cysteine-rich secretory protein 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EDN3 endothelin 3
ERGIC3 ERGIC and golgi 3
FHL2 four and a half LIM domains 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GADD45B growth arrest and DNA-damage-inducible, beta
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HEBP2 heme binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KDM7A lysine (K)-specific demethylase 7A
LAMP1 lysosomal-associated membrane protein 1
LAPTM5 lysosomal protein transmembrane 5
LARP6 La ribonucleoprotein domain family, member 6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
NCAM1 neural cell adhesion molecule 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCP4 Purkinje cell protein 4
PFDN2 prefoldin subunit 2
PHGDH phosphoglycerate dehydrogenase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNF114 ring finger protein 114
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SATB1 SATB homeobox 1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SSR4 signal sequence receptor, delta
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CCDC47 coiled-coil domain containing 47
CCNA2 cyclin A2
CCND3 cyclin D3
CDK4 cyclin-dependent kinase 4
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
ECT2 epithelial cell transforming 2
EMP2 epithelial membrane protein 2
EPHA3 EPH receptor A3
EXT1 exostosin glycosyltransferase 1
FEN1 flap structure-specific endonuclease 1
GAS2L1 growth arrest-specific 2 like 1
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC9 histone deacetylase 9
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGB1BP1 integrin beta 1 binding protein 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHFP lipoma HMGIC fusion partner
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MID1 midline 1
MMD monocyte to macrophage differentiation-associated
MYO1B myosin IB
NDC80 NDC80 kinetochore complex component
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUP107 nucleoporin 107kDa
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OLFM1 olfactomedin 1
OPN3 opsin 3
ORC6 origin recognition complex, subunit 6
OSBPL3 oxysterol binding protein-like 3
PBK PDZ binding kinase
PCDH7 protocadherin 7
PEG10 paternally expressed 10
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RAB40B RAB40B, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF167 ring finger protein 167
RPP25 ribonuclease P/MRP 25kDa subunit
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEH1L SEH1-like (S. cerevisiae)
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SHCBP1 SHC SH2-domain binding protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD6 SMAD family member 6
SMS spermine synthase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STS steroid sulfatase (microsomal), isozyme S
STX1A syntaxin 1A (brain)
SUMO2 small ubiquitin-like modifier 2
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM165 transmembrane protein 165
TMEM194A transmembrane protein 194A
TMEM70 transmembrane protein 70
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSFM Ts translation elongation factor, mitochondrial
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
XPO1 exportin 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta