BRD-K39716612_Fluvastatin sodium salt_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K39716612_Fluvastatin sodium salt_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AREG amphiregulin
ATP11B ATPase, class VI, type 11B
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EZR ezrin
FLOT1 flotillin 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
JUP junction plakoglobin
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LXN latexin
MAGED2 melanoma antigen family D2
MTSS1 metastasis suppressor 1
MVP major vault protein
NRIP1 nuclear receptor interacting protein 1
POSTN periostin, osteoblast specific factor
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RHOA ras homolog family member A
RHOB ras homolog family member B
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATAD2 ATPase family, AAA domain containing 2
C7 complement component 7
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
DERA deoxyribose-phosphate aldolase (putative)
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAUS7 HAUS augmin-like complex, subunit 7
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
ORC6 origin recognition complex, subunit 6
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
SAMD4A sterile alpha motif domain containing 4A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIRP SRA stem-loop interacting RNA binding protein
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C