BRD-K38477985_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K38477985_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MOXD1 monooxygenase, DBH-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RANBP2 RAN binding protein 2
RB1CC1 RB1-inducible coiled-coil 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SYNJ2 synaptojanin 2
TGM2 transglutaminase 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
C5ORF30 chromosome 5 open reading frame 30
CCNB2 cyclin B2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CXCL5 chemokine (C-X-C motif) ligand 5
DPYSL3 dihydropyrimidinase-like 3
GJA1 gap junction protein, alpha 1, 43kDa
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
MFAP5 microfibrillar associated protein 5
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TFRC transferrin receptor
TLR4 toll-like receptor 4
VCAN versican