BRD-K38305202_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K38305202_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AMACR alpha-methylacyl-CoA racemase
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL5A1 collagen, type V, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST1 cystatin SN
CTSB cathepsin B
DEFB1 defensin, beta 1
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EML3 echinoderm microtubule associated protein like 3
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
FADS1 fatty acid desaturase 1
FOLR1 folate receptor 1 (adult)
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IFI44 interferon-induced protein 44
IQGAP2 IQ motif containing GTPase activating protein 2
KLK6 kallikrein-related peptidase 6
KRT10 keratin 10, type I
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS8 lectin, galactoside-binding, soluble, 8
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MYO10 myosin X
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PLA1A phospholipase A1 member A
PPIG peptidylprolyl isomerase G (cyclophilin G)
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SORBS3 sorbin and SH3 domain containing 3
TBL1X transducin (beta)-like 1X-linked
TFCP2L1 transcription factor CP2-like 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22

decreased expression

Symbol Name
ADA adenosine deaminase
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
ANXA10 annexin A10
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD93 CD93 molecule
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CST7 cystatin F (leukocystatin)
CTSE cathepsin E
CYB5R2 cytochrome b5 reductase 2
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAR2 fatty acyl CoA reductase 2
FHL1 four and a half LIM domains 1
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP11 glucuronidase, beta pseudogene 11
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LOXL2 lysyl oxidase-like 2
LY96 lymphocyte antigen 96
MAPT microtubule-associated protein tau
MDFIC MyoD family inhibitor domain containing
MFSD10 major facilitator superfamily domain containing 10
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MZB1 marginal zone B and B1 cell-specific protein
NELL2 NEL-like 2 (chicken)
NRN1 neuritin 1
PCLO piccolo presynaptic cytomatrix protein
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLS3 plastin 3
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RTN2 reticulon 2
S100P S100 calcium binding protein P
SEPT10 septin 10
SH3GLB1 SH3-domain GRB2-like endophilin B1
SNX7 sorting nexin 7
SPRR3 small proline-rich protein 3
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein