BRD-K37865504_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K37865504_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CALD1 caldesmon 1
CD24 CD24 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP1 cysteine and glycine-rich protein 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INHBA inhibin, beta A
JAG1 jagged 1
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LPIN1 lipin 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PRDX1 peroxiredoxin 1
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SMS spermine synthase
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TPM4 tropomyosin 4
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APOE apolipoprotein E
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CA2 carbonic anhydrase II
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COG2 component of oligomeric golgi complex 2
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
COPA coatomer protein complex, subunit alpha
CTSH cathepsin H
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
HBB hemoglobin, beta
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LPAR6 lysophosphatidic acid receptor 6
MDFIC MyoD family inhibitor domain containing
MT1E metallothionein 1E
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNASET2 ribonuclease T2
RNH1 ribonuclease/angiogenin inhibitor 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBC1D31 TBC1 domain family, member 31
TFRC transferrin receptor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIL TLR4 interactor with leucine-rich repeats
WNT5A wingless-type MMTV integration site family, member 5A