BRD-K37691127_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K37691127_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BAD BCL2-associated agonist of cell death
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FBXO11 F-box protein 11
FGG fibrinogen gamma chain
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HILPDA hypoxia inducible lipid droplet-associated
HIPK1 homeodomain interacting protein kinase 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IL1R2 interleukin 1 receptor, type II
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
MAOA monoamine oxidase A
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PALLD palladin, cytoskeletal associated protein
PDIA3 protein disulfide isomerase family A, member 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTHLH parathyroid hormone-like hormone
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQRDL sulfide quinone reductase-like (yeast)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TRIM16 tripartite motif containing 16
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADIRF adipogenesis regulatory factor
CD38 CD38 molecule
HDAC9 histone deacetylase 9
KRT15 keratin 15, type I
LPPR1 lipid phosphate phosphatase-related protein type 1
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
SERINC5 serine incorporator 5
SLAMF7 SLAM family member 7
SOX10 SRY (sex determining region Y)-box 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRBC1 T cell receptor beta constant 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586