BRD-K37687095_AZD-8330_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K37687095_AZD-8330_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
JCHAIN joining chain of multimeric IgA and IgM
KRT17 keratin 17, type I
MAMLD1 mastermind-like domain containing 1
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOV nephroblastoma overexpressed
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTCH1 patched 1
S100A10 S100 calcium binding protein A10
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG4 sperm associated antigen 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ARHGAP29 Rho GTPase activating protein 29
C3AR1 complement component 3a receptor 1
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN10 claudin 10
CSTA cystatin A (stefin A)
CXCL11 chemokine (C-X-C motif) ligand 11
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EREG epiregulin
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
HIST1H4C histone cluster 1, H4c
IER3 immediate early response 3
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
LCN2 lipocalin 2
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
MYLK myosin light chain kinase
NNMT nicotinamide N-methyltransferase
PELI1 pellino E3 ubiquitin protein ligase 1
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SMAD3 SMAD family member 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN5 tetraspanin 5
TSPAN7 tetraspanin 7
YBX3 Y box binding protein 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)