BRD-K37687095_AZD-8330_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA12 carbonic anhydrase XII
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CNPY3 canopy FGF signaling regulator 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
GREB1 growth regulation by estrogen in breast cancer 1
GSR glutathione reductase
HMGB2 high mobility group box 2
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
IL17RB interleukin 17 receptor B
IQGAP2 IQ motif containing GTPase activating protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
MEIS1 Meis homeobox 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OSR2 odd-skipped related transciption factor 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
QPRT quinolinate phosphoribosyltransferase
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
STK26 serine/threonine protein kinase 26
TBX2 T-box 2

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA10 annexin A10
AREG amphiregulin
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CLDN18 claudin 18
COL11A1 collagen, type XI, alpha 1
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA6 GATA binding protein 6
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA6 integrin, alpha 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NFIB nuclear factor I/B
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PTX3 pentraxin 3, long
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
SFRP1 secreted frizzled-related protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
VCAN versican