BRD-K37687095_AZD-8330_MDAMB231_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CRIP1 cysteine-rich protein 1 (intestinal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DMD dystrophin
EAPP E2F-associated phosphoprotein
FTH1 ferritin, heavy polypeptide 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGN3 high mobility group nucleosomal binding domain 3
HSPA2 heat shock 70kDa protein 2
IL1R2 interleukin 1 receptor, type II
LTF lactotransferrin
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODAM odontogenic, ameloblast asssociated
PEX11A peroxisomal biogenesis factor 11 alpha
PIR pirin (iron-binding nuclear protein)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
S100A8 S100 calcium binding protein A8
SULF1 sulfatase 1
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ANXA6 annexin A6
AREG amphiregulin
CD58 CD58 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COTL1 coactosin-like F-actin binding protein 1
CTGF connective tissue growth factor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FZD1 frizzled class receptor 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JUN jun proto-oncogene
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LPP LIM domain containing preferred translocation partner in lipoma
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MACF1 microtubule-actin crosslinking factor 1
MIR22HG MIR22 host gene
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SF1 splicing factor 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TFF3 trefoil factor 3 (intestinal)
TSPAN5 tetraspanin 5
TTC3 tetratricopeptide repeat domain 3
TTN titin
VCL vinculin
VEGFA vascular endothelial growth factor A