BRD-K37687095_AZD-8330_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
BIRC3 baculoviral IAP repeat containing 3
BLVRB biliverdin reductase B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLIC5 chloride intracellular channel 5
COBL cordon-bleu WH2 repeat protein
CP ceruloplasmin (ferroxidase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
ITGAV integrin, alpha V
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
PALLD palladin, cytoskeletal associated protein
PPAP2A phosphatidic acid phosphatase type 2A
PRKCI protein kinase C, iota
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS16 regulator of G-protein signaling 16
RPL37A ribosomal protein L37a
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC2 stanniocalcin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNC1 troponin C type 1 (slow)
TPM2 tropomyosin 2 (beta)
UPK3B uroplakin 3B
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML5 calmodulin-like 5
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CKS1B CDC28 protein kinase regulatory subunit 1B
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HIST1H4C histone cluster 1, H4c
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MMP1 matrix metallopeptidase 1
NCAPG non-SMC condensin I complex, subunit G
NELL2 NEL-like 2 (chicken)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
RRM1 ribonucleotide reductase M1
SDC1 syndecan 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa