BRD-K37687095_AZD-8330_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CUX1 cut-like homeobox 1
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FLNA filamin A, alpha
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
LBH limb bud and heart development
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
OXTR oxytocin receptor
PDGFRL platelet-derived growth factor receptor-like
PIR pirin (iron-binding nuclear protein)
PRKCI protein kinase C, iota
PTGIS prostaglandin I2 (prostacyclin) synthase
RHOQ ras homolog family member Q
RPL37A ribosomal protein L37a
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CDCA4 cell division cycle associated 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
COL13A1 collagen, type XIII, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DUSP6 dual specificity phosphatase 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0101 KIAA0101
LGALS4 lectin, galactoside-binding, soluble, 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
NCAPG2 non-SMC condensin II complex, subunit G2
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS2 protease, serine, 2 (trypsin 2)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RANBP1 RAN binding protein 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM1 ribonucleotide reductase M1
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMTN smoothelin
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRBC1 T cell receptor beta constant 1