BRD-K37687095_AZD-8330_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
C3 complement component 3
CALD1 caldesmon 1
CAPN1 calpain 1, (mu/I) large subunit
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PROS1 protein S (alpha)
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SSPN sarcospan
TAGLN transgelin
THAP11 THAP domain containing 11
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBB6 tubulin, beta 6 class V
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EPN2 epsin 2
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
GOLM1 golgi membrane protein 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHD immunoglobulin heavy constant delta
LIG1 ligase I, DNA, ATP-dependent
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUP85 nucleoporin 85kDa
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRY4 sprouty homolog 4 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TMPO thymopoietin
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein