BRD-K37687095_AZD-8330_MDAMB231_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AMOTL2 angiomotin like 2
AQP1 aquaporin 1 (Colton blood group)
BEX4 brain expressed, X-linked 4
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
COLEC12 collectin sub-family member 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FILIP1L filamin A interacting protein 1-like
FOSL2 FOS-like antigen 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GPC1 glypican 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IL1R1 interleukin 1 receptor, type I
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MUC1 mucin 1, cell surface associated
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PNRC1 proline-rich nuclear receptor coactivator 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SQLE squalene epoxidase
TCF4 transcription factor 4
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
CA2 carbonic anhydrase II
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
ETV5 ets variant 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
ITGA6 integrin, alpha 6
MCM3 minichromosome maintenance complex component 3
MMP1 matrix metallopeptidase 1
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS3 protease, serine, 3
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S