BRD-K37687095_AZD-8330_MDAMB231_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMOTL2 angiomotin like 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
C1S complement component 1, s subcomponent
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CFB complement factor B
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FABP4 fatty acid binding protein 4, adipocyte
FERMT2 fermitin family member 2
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
LDOC1 leucine zipper, down-regulated in cancer 1
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NXN nucleoredoxin
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PTGIS prostaglandin I2 (prostacyclin) synthase
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
TACC1 transforming, acidic coiled-coil containing protein 1
THBS2 thrombospondin 2
TP53I3 tumor protein p53 inducible protein 3
TPM2 tropomyosin 2 (beta)
UPK3B uroplakin 3B
WFS1 Wolfram syndrome 1 (wolframin)
WIF1 WNT inhibitory factor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
IGL immunoglobulin lambda locus
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
PRC1 protein regulator of cytokinesis 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
SVIL supervillin
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN5 tetraspanin 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S