BRD-K37687095_AZD-8330_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADCY1 adenylate cyclase 1 (brain)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK AHNAK nucleoprotein
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
COBL cordon-bleu WH2 repeat protein
DACH1 dachshund family transcription factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GPER1 G protein-coupled estrogen receptor 1
GSN gelsolin
LDOC1 leucine zipper, down-regulated in cancer 1
METTL7A methyltransferase like 7A
MSLN mesothelin
NPY1R neuropeptide Y receptor Y1
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEX11A peroxisomal biogenesis factor 11 alpha
RAB9A RAB9A, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS11 ribosomal protein S11
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SOCS2 suppressor of cytokine signaling 2
SST somatostatin
STAP2 signal transducing adaptor family member 2
TGFBR3 transforming growth factor, beta receptor III

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA1 annexin A1
CCND1 cyclin D1
CD200 CD200 molecule
CDC45 cell division cycle 45
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
HAPLN1 hyaluronan and proteoglycan link protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT23 keratin 23, type I
LOXL1 lysyl oxidase-like 1
LRRC15 leucine rich repeat containing 15
PDGFC platelet derived growth factor C
PLAU plasminogen activator, urokinase
PYGL phosphorylase, glycogen, liver
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SDC1 syndecan 1
SPRED2 sprouty-related, EVH1 domain containing 2
TAGLN transgelin
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
VEGFA vascular endothelial growth factor A