BRD-K37687095_AZD-8330_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF3 chromosome 9 open reading frame 3
COL9A2 collagen, type IX, alpha 2
ESR1 estrogen receptor 1
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
HOXC6 homeobox C6
KIAA1598
KRT15 keratin 15, type I
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS2 lectin, galactoside-binding, soluble, 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
POU2AF1 POU class 2 associating factor 1
PRAME preferentially expressed antigen in melanoma
RBPMS RNA binding protein with multiple splicing
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOCS2 suppressor of cytokine signaling 2
SPP1 secreted phosphoprotein 1
THAP11 THAP domain containing 11
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA10 annexin A10
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ASPN asporin
CCND1 cyclin D1
CCNE2 cyclin E2
COL3A1 collagen, type III, alpha 1
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5A cytochrome b5 type A (microsomal)
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
ITGB5 integrin, beta 5
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1E metallothionein 1E
MT1M metallothionein 1M
PPARG peroxisome proliferator-activated receptor gamma
PROSC proline synthetase co-transcribed homolog (bacterial)
PRSS23 protease, serine, 23
PRSS3 protease, serine, 3
RANBP1 RAN binding protein 1
SCCPDH saccharopine dehydrogenase (putative)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb