BRD-K37687095_AZD-8330_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD36B ankyrin repeat domain 36B
COL4A5 collagen, type IV, alpha 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPER1 G protein-coupled estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HEBP1 heme binding protein 1
HLF hepatic leukemia factor
IGKC immunoglobulin kappa constant
KRT6A keratin 6A, type II
LYN LYN proto-oncogene, Src family tyrosine kinase
PSD3 pleckstrin and Sec7 domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
CCNE2 cyclin E2
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
DUSP4 dual specificity phosphatase 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL1 lysyl oxidase-like 1
LYZ lysozyme
MAOB monoamine oxidase B
MTERF3 mitochondrial transcription termination factor 3
PPARG peroxisome proliferator-activated receptor gamma
SCCPDH saccharopine dehydrogenase (putative)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SOX9 SRY (sex determining region Y)-box 9
SVIL supervillin
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4