BRD-K37687095_AZD-8330_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
CYTIP cytohesin 1 interacting protein
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
HIST1H2AC histone cluster 1, H2ac
HMGN3 high mobility group nucleosomal binding domain 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
OXTR oxytocin receptor
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRAME preferentially expressed antigen in melanoma
QPRT quinolinate phosphoribosyltransferase
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SLAMF7 SLAM family member 7
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPAG5 sperm associated antigen 5
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STOM stomatin
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL5 acyl-CoA synthetase long-chain family member 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
CD52 CD52 molecule
COL9A3 collagen, type IX, alpha 3
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
FXYD6 FXYD domain containing ion transport regulator 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KLF10 Kruppel-like factor 10
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYC v-myc avian myelocytomatosis viral oncogene homolog
NGRN neugrin, neurite outgrowth associated
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1