BRD-K37687095_AZD-8330_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ASCL1 achaete-scute family bHLH transcription factor 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
EFHD1 EF-hand domain family, member D1
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KIF5C kinesin family member 5C
KRT7 keratin 7, type II
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TSPYL4 TSPY-like 4
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BHLHE40 basic helix-loop-helix family, member e40
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV4 ets variant 4
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX2 sushi-repeat containing protein, X-linked 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TSPAN5 tetraspanin 5
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1