BRD-K37687095_AZD-8330_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CCDC53 coiled-coil domain containing 53
CD14 CD14 molecule
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DSP desmoplakin
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGF9 fibroblast growth factor 9
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUND jun D proto-oncogene
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMOD1 leiomodin 1 (smooth muscle)
MATN2 matrilin 2
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRSS8 protease, serine, 8
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS1 regulator of G-protein signaling 1
RPL31 ribosomal protein L31
RPL39L ribosomal protein L39-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEAL4 transcription elongation factor A (SII)-like 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV5 ets variant 5
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSCN1 fascin actin-bundling protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein