BRD-K37687095_AZD-8330_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLVRB biliverdin reductase B
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
COL1A1 collagen, type I, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM134B family with sequence similarity 134, member B
FGB fibrinogen beta chain
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUP junction plakoglobin
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KYNU kynureninase
LAGE3 L antigen family, member 3
LAMA5 laminin, alpha 5
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGES prostaglandin E synthase
RAB25 RAB25, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
S100A14 S100 calcium binding protein A14
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTSSA serine palmitoyltransferase, small subunit A
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC2 transforming, acidic coiled-coil containing protein 2
TCEAL4 transcription elongation factor A (SII)-like 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM59 transmembrane protein 59
TMOD1 tropomodulin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VAV3 vav 3 guanine nucleotide exchange factor
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPN2 calpain 2, (m/II) large subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV5 ets variant 5
EXO1 exonuclease 1
EXOSC9 exosome component 9
EXT1 exostosin glycosyltransferase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FANCG Fanconi anemia, complementation group G
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
FZD7 frizzled class receptor 7
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRY2 sprouty homolog 2 (Drosophila)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein