BRD-K37687095_AZD-8330_MCF10A_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

325 genes differentially expressed following the BRD-K37687095_AZD-8330_MCF10A_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD47 CD47 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN7 claudin 7
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTSD cathepsin D
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FGF9 fibroblast growth factor 9
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUP junction plakoglobin
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMK2 LIM domain kinase 2
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MATN2 matrilin 2
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PALLD palladin, cytoskeletal associated protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRSS8 protease, serine, 8
PSAP prosaposin
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A4 S100 calcium binding protein A4
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STK38L serine/threonine kinase 38 like
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO synaptopodin
SYT17 synaptotagmin XVII
TACSTD2 tumor-associated calcium signal transducer 2
TCEAL4 transcription elongation factor A (SII)-like 4
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TRAPPC6A trafficking protein particle complex 6A
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAMP8 vesicle-associated membrane protein 8
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV5 ets variant 5
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NOP56 NOP56 ribonucleoprotein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SMOX spermine oxidase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein