BRD-K37687095_AZD-8330_HT29_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

336 genes differentially expressed following the BRD-K37687095_AZD-8330_HT29_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMACR alpha-methylacyl-CoA racemase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CREBL2 cAMP responsive element binding protein-like 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO5 flavin containing monooxygenase 5
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GCC2 GRIP and coiled-coil domain containing 2
GLS glutaminase
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LXN latexin
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MID1 midline 1
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MT1F metallothionein 1F
MT1X metallothionein 1X
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB17 RAB17, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBM47 RNA binding motif protein 47
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USH1C Usher syndrome 1C (autosomal recessive, severe)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWA5A von Willebrand factor A domain containing 5A
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CBFB core-binding factor, beta subunit
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DCTPP1 dCTP pyrophosphatase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EXOSC2 exosome component 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FASN fatty acid synthase
FAT1 FAT atypical cadherin 1
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
INPP1 inositol polyphosphate-1-phosphatase
IPO7 importin 7
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KLF2 Kruppel-like factor 2
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP210 nucleoporin 210kDa
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
SEH1L SEH1-like (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35F2 solute carrier family 35, member F2
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPX2 TPX2, microtubule-associated
TRAP1 TNF receptor-associated protein 1
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
VCAN versican
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing