BRD-K37687095_AZD-8330_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLDN10 claudin 10
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM46A family with sequence similarity 46, member A
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
GUSBP11 glucuronidase, beta pseudogene 11
JCHAIN joining chain of multimeric IgA and IgM
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LAMP5 lysosomal-associated membrane protein family, member 5
MAOA monoamine oxidase A
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELN reelin
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
THAP11 THAP domain containing 11
TPM2 tropomyosin 2 (beta)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CLC Charcot-Leyden crystal galectin
CLDN4 claudin 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
EPAS1 endothelial PAS domain protein 1
ETV1 ets variant 1
EZR ezrin
F5 coagulation factor V (proaccelerin, labile factor)
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
JUN jun proto-oncogene
KRT23 keratin 23, type I
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
WLS wntless Wnt ligand secretion mediator