BRD-K37687095_AZD-8330_HS578T_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
APOE apolipoprotein E
BGN biglycan
CCND2 cyclin D2
CPE carboxypeptidase E
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPR137B G protein-coupled receptor 137B
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
ITM2A integral membrane protein 2A
LYZ lysozyme
MAOB monoamine oxidase B
MT1M metallothionein 1M
PDZK1 PDZ domain containing 1
PVALB parvalbumin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STXBP2 syntaxin binding protein 2
TYROBP TYRO protein tyrosine kinase binding protein
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
BOP1 block of proliferation 1
CCND1 cyclin D1
CEP170 centrosomal protein 170kDa
CHIC2 cysteine-rich hydrophobic domain 2
COL4A5 collagen, type IV, alpha 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
HMGA2 high mobility group AT-hook 2
IGHM immunoglobulin heavy constant mu
JUN jun proto-oncogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MMD monocyte to macrophage differentiation-associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2C phosphatidic acid phosphatase type 2C
PRKCH protein kinase C, eta
PTX3 pentraxin 3, long
SFRP1 secreted frizzled-related protein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SVIL supervillin
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1