BRD-K37687095_AZD-8330_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALCAM activated leukocyte cell adhesion molecule
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BRD2 bromodomain containing 2
BST2 bone marrow stromal cell antigen 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHN1 chimerin 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDR1 discoidin domain receptor tyrosine kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
EVL Enah/Vasp-like
FAM46A family with sequence similarity 46, member A
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LCN2 lipocalin 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NQO2 NAD(P)H dehydrogenase, quinone 2
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PALLD palladin, cytoskeletal associated protein
PDIA5 protein disulfide isomerase family A, member 5
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G16 phospholipase A2, group XVI
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRDX2 peroxiredoxin 2
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RAB9A RAB9A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SQLE squalene epoxidase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNGR3 synaptogyrin 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMBP dynamin binding protein
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EREG epiregulin
ETV1 ets variant 1
EXO1 exonuclease 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KLF4 Kruppel-like factor 4 (gut)
KNTC1 kinetochore associated 1
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RECQL RecQ helicase-like
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEH1L SEH1-like (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TFAM transcription factor A, mitochondrial
TLR4 toll-like receptor 4
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP6 thyroid hormone receptor interactor 6
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein