BRD-K37687095_AZD-8330_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADA adenosine deaminase
APOC1 apolipoprotein C-I
ARMCX3 armadillo repeat containing, X-linked 3
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BACE2 beta-site APP-cleaving enzyme 2
BIRC3 baculoviral IAP repeat containing 3
BLVRB biliverdin reductase B
CCR7 chemokine (C-C motif) receptor 7
CD300A CD300a molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CLU clusterin
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
DENND2D DENN/MADD domain containing 2D
EBI3 Epstein-Barr virus induced 3
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
ITGAV integrin, alpha V
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
LCN2 lipocalin 2
LPIN1 lipin 1
LPL lipoprotein lipase
LXN latexin
MBNL2 muscleblind-like splicing regulator 2
MGLL monoglyceride lipase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
PAWR PRKC, apoptosis, WT1, regulator
PDIA5 protein disulfide isomerase family A, member 5
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PLXNB2 plexin B2
PON2 paraoxonase 2
PROM1 prominin 1
RAB9A RAB9A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RRAGD Ras-related GTP binding D
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNX11 sorting nexin 11
STOM stomatin
SYNGR3 synaptogyrin 3
TFF3 trefoil factor 3 (intestinal)
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRAF5 TNF receptor-associated factor 5
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EFHD2 EF-hand domain family, member D2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
EXO1 exonuclease 1
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HJURP Holliday junction recognition protein
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LPAR1 lysophosphatidic acid receptor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PRC1 protein regulator of cytokinesis 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSPH phosphoserine phosphatase
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SMAGP small cell adhesion glycoprotein
SMC1A structural maintenance of chromosomes 1A
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMELESS timeless circadian clock
TMEM194A transmembrane protein 194A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
VSNL1 visinin-like 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein