BRD-K37687095_AZD-8330_HS578T_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
CA12 carbonic anhydrase XII
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EXOSC4 exosome component 4
FAM117A family with sequence similarity 117, member A
FBN1 fibrillin 1
FERMT2 fermitin family member 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSBP1 heat shock factor binding protein 1
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
JAM3 junctional adhesion molecule 3
KDM5B lysine (K)-specific demethylase 5B
KRT14 keratin 14, type I
LCN2 lipocalin 2
LIMS1 LIM and senescent cell antigen-like domains 1
LPIN1 lipin 1
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MYH10 myosin, heavy chain 10, non-muscle
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PDIA5 protein disulfide isomerase family A, member 5
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RHOQ ras homolog family member Q
RNF144A ring finger protein 144A
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
STK26 serine/threonine protein kinase 26
STOM stomatin
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
EFHD2 EF-hand domain family, member D2
EGR2 early growth response 2
ETV1 ets variant 1
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG2 non-SMC condensin II complex, subunit G2
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRP1 neuropilin 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC4 structural maintenance of chromosomes 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TIMELESS timeless circadian clock
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein