BRD-K37687095_AZD-8330_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K37687095_AZD-8330_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ACPP acid phosphatase, prostate
ACSF2 acyl-CoA synthetase family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ANXA9 annexin A9
APOE apolipoprotein E
BLNK B-cell linker
BLVRB biliverdin reductase B
C1ORF115 chromosome 1 open reading frame 115
C5 complement component 5
CAT catalase
CCNG1 cyclin G1
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHI3L2 chitinase 3-like 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GM2A GM2 ganglioside activator
HDAC6 histone deacetylase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HP haptoglobin
HSDL2 hydroxysteroid dehydrogenase like 2
IFI30 interferon, gamma-inducible protein 30
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF2C kinesin family member 2C
KNG1 kininogen 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NDFIP1 Nedd4 family interacting protein 1
NEFH neurofilament, heavy polypeptide
NMRK1 nicotinamide riboside kinase 1
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
QDPR quinoid dihydropteridine reductase
QPRT quinolinate phosphoribosyltransferase
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SFTPA2 surfactant protein A2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AEBP1 AE binding protein 1
AGO2 argonaute RISC catalytic component 2
AKAP12 A kinase (PRKA) anchor protein 12
ANO1 anoctamin 1, calcium activated chloride channel
ASPN asporin
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42 cell division cycle 42
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP6 dual specificity phosphatase 6
EBNA1BP2 EBNA1 binding protein 2
EGR3 early growth response 3
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAP fibroblast activation protein, alpha
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GSPT1 G1 to S phase transition 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGA1 high mobility group AT-hook 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP2K3 mitogen-activated protein kinase kinase 3
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM3 PDZ and LIM domain 3
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS4 regulator of G-protein signaling 4
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SEH1L SEH1-like (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPBG trophoblast glycoprotein
TXN thioredoxin
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1