BRD-K37687095_AZD-8330_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K37687095_AZD-8330_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADGRL3 adhesion G protein-coupled receptor L3
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHMT betaine--homocysteine S-methyltransferase
C5 complement component 5
CAT catalase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK14 cyclin-dependent kinase 14
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CLU clusterin
CRYAB crystallin, alpha B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DENND2D DENN/MADD domain containing 2D
EFNA1 ephrin-A1
EFS embryonal Fyn-associated substrate
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FDPS farnesyl diphosphate synthase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HECA headcase homolog (Drosophila)
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KLHDC2 kelch domain containing 2
LIMCH1 LIM and calponin homology domains 1
LYPD1 LY6/PLAUR domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NBR1 neighbor of BRCA1 gene 1
NFIL3 nuclear factor, interleukin 3 regulated
NINJ1 ninjurin 1
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PVALB parvalbumin
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TF transferrin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
COL1A1 collagen, type I, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A3 collagen, type VI, alpha 3
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP8 GTP-binding protein 8 (putative)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MRPS16 mitochondrial ribosomal protein S16
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NUP88 nucleoporin 88kDa
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PUS7 pseudouridylate synthase 7 (putative)
RCC1 regulator of chromosome condensation 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC3 trafficking protein particle complex 3
TSPAN5 tetraspanin 5
VCAN versican
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing