BRD-K37687095_AZD-8330_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K37687095_AZD-8330_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALAD aminolevulinate dehydratase
ASS1 argininosuccinate synthase 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C5 complement component 5
CADM1 cell adhesion molecule 1
CAT catalase
CCNG1 cyclin G1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
KIAA1598
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NREP neuronal regeneration related protein
PDGFD platelet derived growth factor D
PDZK1 PDZ domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE prune exopolyphosphatase
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNN stannin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP2 syntaxin binding protein 2
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
BMP4 bone morphogenetic protein 4
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM3C family with sequence similarity 3, member C
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT8 keratin 8, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PDAP1 PDGFA associated protein 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
POU2AF1 POU class 2 associating factor 1
PRKCH protein kinase C, eta
PRMT1 protein arginine methyltransferase 1
RBPMS RNA binding protein with multiple splicing
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STK17A serine/threonine kinase 17a
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UBE2S ubiquitin-conjugating enzyme E2S