BRD-K37687095_AZD-8330_HCC515_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K37687095_AZD-8330_HCC515_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARMCX3 armadillo repeat containing, X-linked 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUH AU RNA binding protein/enoyl-CoA hydratase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CAT catalase
CCNG2 cyclin G2
CD14 CD14 molecule
CD163 CD163 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CLU clusterin
COPG1 coatomer protein complex, subunit gamma 1
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAIM Fas apoptotic inhibitory molecule
FAM134B family with sequence similarity 134, member B
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPER1 G protein-coupled estrogen receptor 1
GRB14 growth factor receptor-bound protein 14
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL6ST interleukin 6 signal transducer
IRF7 interferon regulatory factor 7
JUP junction plakoglobin
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PDZK1 PDZ domain containing 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PODXL podocalyxin-like
PROM1 prominin 1
PRSS23 protease, serine, 23
PSAP prosaposin
RBM47 RNA binding motif protein 47
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SYNE2 spectrin repeat containing, nuclear envelope 2
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TM7SF2 transmembrane 7 superfamily member 2
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ETV1 ets variant 1
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFIB nuclear factor I/B
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC2 structural maintenance of chromosomes 2
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein