BRD-K37687095_AZD-8330_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K37687095_AZD-8330_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXOSC4 exosome component 4
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL1R1 interleukin 1 receptor, type I
IRF9 interferon regulatory factor 9
KLF9 Kruppel-like factor 9
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MGP matrix Gla protein
NAV2 neuron navigator 2
NDRG2 NDRG family member 2
NEB nebulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLPI secretory leukocyte peptidase inhibitor
SORBS1 sorbin and SH3 domain containing 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TNNC2 troponin C type 2 (fast)
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TTN titin
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ANXA10 annexin A10
CD200 CD200 molecule
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
LXN latexin
MAP7 microtubule-associated protein 7
NAP1L1 nucleosome assembly protein 1-like 1
PCDH9 protocadherin 9
POU2AF1 POU class 2 associating factor 1
RBM25 RNA binding motif protein 25
RBM3 RNA binding motif (RNP1, RRM) protein 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAG2 stromal antigen 2
TBX2 T-box 2
TSPAN4 tetraspanin 4
VCAN versican
ZBTB38 zinc finger and BTB domain containing 38