BRD-K37687095_AZD-8330_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K37687095_AZD-8330_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASPN asporin
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
CD47 CD47 molecule
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
FAM107A family with sequence similarity 107, member A
FGFR2 fibroblast growth factor receptor 2
GBP1 guanylate binding protein 1, interferon-inducible
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
MGP matrix Gla protein
MPPED2 metallophosphoesterase domain containing 2
MX1 MX dynamin-like GTPase 1
NAV2 neuron navigator 2
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM3 PDZ and LIM domain 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLSCR1 phospholipid scramblase 1
PPAP2A phosphatidic acid phosphatase type 2A
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS1 regulator of G-protein signaling 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SORBS1 sorbin and SH3 domain containing 1
SPARCL1 SPARC-like 1 (hevin)
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA5 annexin A5
ASPH aspartate beta-hydroxylase
CCND1 cyclin D1
CDC20 cell division cycle 20
DKK1 dickkopf WNT signaling pathway inhibitor 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
HMGA2 high mobility group AT-hook 2
HOXB6 homeobox B6
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
RANBP1 RAN binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SFRP1 secreted frizzled-related protein 1
SRSF10 serine/arginine-rich splicing factor 10
STEAP3 STEAP family member 3, metalloreductase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)