BRD-K37687095_AZD-8330_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K37687095_AZD-8330_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CAT catalase
CCNG2 cyclin G2
CD93 CD93 molecule
CD99 CD99 molecule
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL14 chemokine (C-X-C motif) ligand 14
DAZAP2 DAZ associated protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM134B family with sequence similarity 134, member B
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP1 formin binding protein 1
FNBP1L formin binding protein 1-like
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GPR137B G protein-coupled receptor 137B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBB hemoglobin, beta
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
JAK1 Janus kinase 1
KIAA1598
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LAMA3 laminin, alpha 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NCK1 NCK adaptor protein 1
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REG1A regenerating islet-derived 1 alpha
S100A10 S100 calcium binding protein A10
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
SYNPO synaptopodin
TAGLN2 transgelin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TTC39A tetratricopeptide repeat domain 39A
VAMP8 vesicle-associated membrane protein 8
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADCK3 aarF domain containing kinase 3
AKAP12 A kinase (PRKA) anchor protein 12
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C5 complement component 5
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CCP110 centriolar coiled coil protein 110kDa
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CDT1 chromatin licensing and DNA replication factor 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CIT citron rho-interacting serine/threonine kinase
CLC Charcot-Leyden crystal galectin
CLGN calmegin
COCH cochlin
COL13A1 collagen, type XIII, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNA2 DNA replication helicase/nuclease 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREM1 gremlin 1, DAN family BMP antagonist
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
ISL1 ISL LIM homeobox 1
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KLK11 kallikrein-related peptidase 11
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MEIS2 Meis homeobox 2
MLPH melanophilin
MMP9 matrix metallopeptidase 9
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
OLFML3 olfactomedin-like 3
PAX5 paired box 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein