BRD-K37687095_AZD-8330_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K37687095_AZD-8330_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADARB1 adenosine deaminase, RNA-specific, B1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX4 brain expressed, X-linked 4
CAT catalase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAZAP2 DAZ associated protein 2
DLG5 discs, large homolog 5 (Drosophila)
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EPS8L2 EPS8-like 2
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GRAMD3 GRAM domain containing 3
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KLF11 Kruppel-like factor 11
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LOX lysyl oxidase
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MMP7 matrix metallopeptidase 7
NDRG1 N-myc downstream regulated 1
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNGR3 synaptogyrin 3
TAGLN2 transgelin 2
THBS2 thrombospondin 2
TRAM2 translocation associated membrane protein 2
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK2 ankyrin 2, neuronal
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ASRGL1 asparaginase like 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C5 complement component 5
C7 complement component 7
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CHEK1 checkpoint kinase 1
CHL1 cell adhesion molecule L1-like
CRISP3 cysteine-rich secretory protein 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KLK11 kallikrein-related peptidase 11
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TNC tenascin C
TSPAN5 tetraspanin 5
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein